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KMID : 0368019890120030251
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Journal of Soonchunhyang University
1989 Volume.12 No. 3 p.251 ~ p.256
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Fine Structure of the Gastric Mucous Cell Following Adrenalectomy
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양남길/Yang, Nam-Gil
구광일/안의태/고정식/박경호/Koo, Kwang-Il/Ahn, E-Tay/Ko, Jeong-Sik/Park, Kyung-Ho
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Abstract
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The experiment was conducted on the male Sprague-Dawley rats weighing about 250g each, to study the fine structural changes of the gastric muscus-secreting cells following bilateral adrenlectomy. Adrenalectomy was performed by dorsal approach method under ether anesthesia. Animals are fe ad libitum after the operation. The normal and the adrenalectomized rats were sacreificed on the 1st, 3rd, 5th and 7th day after the operation.
For the electron microscopic observation, gastric mucosae were fixed in 2.5% glutaraldehyde-1.5% paraformaldehyde follewed by post fixation in 1% osmium tetroxide. The ultrathin sections were contrasted with uranyl acetate and lead citrate, and examined with JEM 100CX Ⅱ electrom microscope.
Obtained results were follows:
1. The gastrric surfae mucous cells of adrenalectomized rat contained mucoud granules of less electron density than those of the normal rat contains. And mucous granules of adrenalectomized rats are usually placed apart from the surface plasma membrane.
2. Goblet cells of adrenaletomized rat exhibited well formed microvilli as compared with those of normal rat.
3. Cell differentiation in the isthmic area was generally seem to be delayed following adrenalectomy.
4. Golgi complexes of goblet cells were influenced by adrenalectomy, showing flattening or discrganization of cistems, non-typical vacuoles, scanty vesicles, etc.
5. Considering the above findings, adrenalectomy probably causes the dysfunction of the gastric mucus cellthat results in delayed mucus formation and secretion.
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